Research on the biochemistry and molecular biology of lipids and lipoproteins has experienced remarkable growth in the last 20 years, particularly with the realization that many different classes of lipids play fundamental roles in diseases such as heart disease, obesity, diabetes, cancer and neurodegenerative disorders. The 5th edition of this book has been written with two major objectives. The first objective is to provide students and teachers with an advanced up-to-date textbook covering the major areas of current interest in the lipid field. The chapters are written for students and researchers familiar with the general concepts of lipid metabolism but who wish to expand their knowledge in this area. The second objective is to provide a reference text for scientists who are about to enter the field of lipids, lipoproteins and membranes and who wish to learn more about this area of research. All of the chapters have been extensively updated since the 4th edition appeared in 2002.
Key Features:
* Represents a bridge between the superficial coverage of the lipid field found in basic biochemistry text books and the highly specialized material contained in scientific review articles and monographs.
* Allows scientists to become familiar with recent developments related to their own research interests, and will help clinical researchers and medical students keep abreast of developments in basic science that are important for subsequent clinical advances.
* Serves as a general reference book for scientists studying lipids, lipoproteins and membranes and as an advanced and up-to-date textbook for teachers and students who are familiar with the basic concepts of lipid biochemistry.
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The Guidelines PocketGuide is a spiral-bound pocket guide containing society-endorsed evidence-based treatment guidelines in a brief algorithmic format that is most preferred by practicing clinicians, quality managers, nurses, educators, and medical students. The Lipid and Lipoprotein Disorders: Current Clinical Solutions PocketGuide is a practical quick-reference tool containing screening, diagnostic, treatment algorithm, drug therapy, dosing information, patient monitoring, and counseling points. It provides all that is needed to make accurate clinical decisions at the point of care including lipid/lipoprotein physiology and definitions, major cardiovascular risk factors, risk factors associated with the metabolic syndrome estimate of ten-year risk for men and women, current medication tables with brand and generic names, detailed drug information including strengths, formulations, and comments.
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High-density lipoprotein, HDL, is one of the hottest topics in lipid research and cardiovascular disease prevention today. Emphasizing the functional properties of HDL and covering emerging therapeutic targets and roles for cardiovascular disease, this book summarizes the current state of knowledge in a rapidly growing domain at the interface between lipidology and cardiovascular therapies and treatments. It presents evaluative assays, extensively reviews HDL particles' functional, compositional, and metabolic heterogeneity (with special attention given to potent atheroprotective properties of small, dense HDL), and compares current and future HDL-raising therapies.
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Jose Ordovas compiles a cutting-edge collection of molecular protein techniques for studying advanced aspects of lipoprotein structure and metabolism. These step-by-step methods allow both the beginning and the advanced researcher to carry out not only fundamental, but also the most advanced genetic screening techniques, including RT-PCR and the preparation of relevant models of transgenic and knockout mice. In addition, novel techniques are presented to characterize plasma lipoproteins, their subfractions, and their modifications, and to determine the activity of relevant enzymes and carrier proteins. Each method is described in easily reproducible detail by a hands-on expert who has perfected it. Lipoprotein Protocols offers many powerful tools for unraveling the complexity of lipoprotein metabolism and determining the individual risk of coronary heart disease.
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Lowering heart risk
Hindustan Times - Sep 24, 2011
3) Keep low-density lipoprotein (LDL or bad 4) High-density lipoprotein (HDL or good cholesterol) over 45 mg/dl for men and over 55 mg/dl for women. 5) Keep triglycerides (blood fats) below 150 mg/dl. If triglycerides are over 500, lower them before
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New insights into the mechanism of low high-density lipoprotein cholesterol in ...
7thSpace Interactive (press release) - Oct 17, 2063
Obesity, a significant risk factor for various chronic diseases, is universally related to dyslipidemia mainly represented by decreasing high-density lipoprotein cholesterol (HDL-C), which plays an indispensible role in development of cardiovascular
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Comparison of Diet Consumption, Body Composition and Lipoprotein Lipid Values ...
7thSpace Interactive (press release) - Oct 17, 6243
The purpose of this investigation was to : 1) collect baseline data on nutrient intake 2) collect, analyze and report baseline for body composition, plasma lipid and lipoprotein concentrations during the competitive season, 3) compare the results with
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Gastric Bypass at 6 Years: Diabetes Remission Maintained
Family Practice News Digital Network - Oct 10, 2011
Significant reductions in waist circumference, systolic blood pressure, heart rate, triglycerides, low-density-lipoprotein cholesterol, and insulin resistance were maintained at 6 years in the surgical group, as were higher levels of high-density
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Mediterranean Diet Nutrients Benefit Heart
17.10.44
2011 March/April;40-2 ). Supplements that contain these natural ingredients may therefore help reduce the growing incidence of CVD.
"There are several historically-used measurements for identifying individuals at risk for developing cardiovascular disease, including levels of LDL- and high-density lipoprotein (HDL) cholesterol, total cholesterol and high blood pressure to name a few," Evans noted. "However, there are other biomarkers, including OxLDL and the OxLDL / HDL cholesterol ratio that have been shown in clinical research to be more sensitive indicators for discriminating between individuals with and without coronary artery disease (CAD) when compared to the commonly measured biomarkers. And consuming a Mediterranean diet is an effective way to reduce levels of OxLDL and improve overall cardiovascular health.
Source: Natural Products INSIDER
Very-Low-Density Lipoprotein: Complex Particles in Cardiac Energy ...
Abstract
The heart is a major consumer of energy and is able to utilise a wide range of substrates including lipids. Nonesterified fatty acids (NEFA) were thought to be a favoured carbon source, but their quantitative contribution is limited because of their relative histotoxicity. Circulating triacylglycerols (TAGs) in the form of chylomicrons (CMs) and very-low-density lipoprotein (VLDL) are an alternative source of fatty acids and are now believed to be important in cardiac metabolism. However, few studies on cardiac utilisation of VLDL have been performed and the role of VLDL in cardiac energy metabolism remains unclear. Hearts utilise VLDL to generate ATP, but the oxidation rate of VLDL-TAG is relatively low under physiological conditions; however, in certain pathological states switching of energy substrates occurs and VLDL may become a major energy source for hearts. We review research regarding myocardial utilisation of VLDL and suggest possible roles of VLDL in cardiac energy metabolism: metabolic regulator and extracardiac energy storage for hearts.
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Lipoprotein(a) is strongly associated with coronary artery calcification in type-2 diabetic women: ... .
RT : Niaccin is a B vitamin that may increase levels of “good” high-density lipoprotein (HDL) cholesterol by 15 to 35 percent..
Niaccin is a B vitamin that may increase levels of “good” high-density lipoprotein (HDL) cholesterol by 15 to 35 percent..
Inhibition of Atherosclerosis in Low-Density Lipoprotein Receptor-Negative Mice by Sesame Oil .
Predictors of Coronary Heart Disease Events Among Asymptomatic Persons With Low Low-Density Lipoprotein Cholesterol. .